| ANDATA | ||
| 1ª Giornata | ||
| 2021-09-26 | Appignanese - E. Cascinare | 2-1 |
| 2021-09-26 | Caldarola GNC - CSKA Amatori | 1-3 |
| 2021-09-26 | Camerino - Matelica | 1-1 |
| 2021-09-26 | Casette Verd. - Settempeda | 1-0 |
| 2021-09-26 | Castelraimondo - Montemilone P. | 0-0 |
| 2021-09-26 | Elfa Tolentino - Urbis Salvia | 2-0 |
| 2021-09-26 | Pioraco - San Biagio | 2-2 |
| 2021-09-26 | Villa Musone - San Claudio | 1-0 |
| 2ª Giornata | ||
| 2021-10-03 | CSKA Amatori - Casette Verd. | 0-1 |
| 2021-10-03 | E. Cascinare - Elfa Tolentino | 2-3 |
| 2021-10-03 | Matelica - Pioraco | 4-1 |
| 2021-10-03 | Montemilone P. - Appignanese | 2-2 |
| 2021-10-03 | San Biagio - Villa Musone | 0-2 |
| 2021-10-03 | San Claudio - Castelraimondo | 1-0 |
| 2021-10-03 | Settempeda - Camerino | 0-1 |
| 2021-10-03 | Urbis Salvia - Caldarola GNC | 2-0 |
| 3ª Giornata | ||
| 2021-10-10 | Appignanese - CSKA Amatori | 2-1 |
| 2021-10-10 | Caldarola GNC - Settempeda | 1-1 |
| 2021-10-10 | Camerino - San Claudio | 1-0 |
| 2021-10-10 | Castelraimondo - Urbis Salvia | 2-4 |
| 2021-10-10 | Elfa Tolentino - Casette Verd. | 2-1 |
| 2021-10-10 | Matelica - San Biagio | 3-0 |
| 2021-10-10 | Pioraco - Montemilone P. | 1-1 |
| 2021-10-10 | Villa Musone - E. Cascinare | 1-1 |
| 4ª Giornata | ||
| 2021-10-17 | Casette Verd. - Caldarola GNC | 2-3 |
| 2021-10-17 | CSKA Amatori - Elfa Tolentino | 0-1 |
| 2021-10-17 | E. Cascinare - Castelraimondo | 1-0 |
| 2021-10-17 | Montemilone P. - Villa Musone | 4-0 |
| 2021-10-17 | San Biagio - Camerino | 1-0 |
| 2021-10-17 | San Claudio - Pioraco | 0-1 |
| 2021-10-17 | Settempeda - Matelica | 1-1 |
| 2021-10-17 | Urbis Salvia - Appignanese | 1-3 |
| 5ª Giornata | ||
| 2021-10-24 | Appignanese - Caldarola GNC | 0-2 |
| 2021-10-24 | Camerino - E. Cascinare | 0-0 |
| 2021-10-24 | Castelraimondo - Casette Verd. | 3-0 |
| 2021-10-24 | Elfa Tolentino - Settempeda | 1-0 |
| 2021-10-24 | Matelica - Montemilone P. | 0-0 |
| 2021-10-24 | Pioraco - Urbis Salvia | 1-1 |
| 2021-10-24 | San Biagio - San Claudio | 2-3 |
| 2021-10-24 | Villa Musone - CSKA Amatori | 2-2 |
| 6ª Giornata | ||
| 2021-10-31 | Caldarola GNC - Elfa Tolentino | 0-3 |
| 2021-10-31 | Casette Verd. - Appignanese | 0-2 |
| 2021-10-31 | CSKA Amatori - Castelraimondo | 2-0 |
| 2021-10-31 | E. Cascinare - Pioraco | 1-3 |
| 2021-10-31 | Montemilone P. - Camerino | 1-0 |
| 2021-10-31 | San Claudio - Matelica | 0-2 |
| 2021-10-31 | Settempeda - San Biagio | 3-1 |
| 2021-10-31 | Urbis Salvia - Villa Musone | 2-0 |
| 7ª Giornata | ||
| 2021-11-07 | Appignanese - Settempeda | 2-0 |
| 2021-11-07 | Camerino - CSKA Amatori | 2-0 |
| 2021-11-07 | Castelraimondo - Elfa Tolentino | 1-2 |
| 2021-11-07 | Matelica - Urbis Salvia | 5-2 |
| 2021-11-07 | Pioraco - Casette Verd. | 0-1 |
| 2021-11-07 | San Biagio - E. Cascinare | 1-1 |
| 2021-11-07 | San Claudio - Montemilone P. | 0-3 |
| 2021-11-07 | Villa Musone - Caldarola GNC | 3-3 |
| 8ª Giornata | ||
| 2021-11-14 | Caldarola GNC - Castelraimondo | 1-0 |
| 2021-11-14 | Casette Verd. - Villa Musone | 3-1 |
| 2021-11-14 | CSKA Amatori - Pioraco | 1-0 |
| 2021-11-14 | E. Cascinare - Matelica | 0-1 |
| 2021-11-14 | Elfa Tolentino - Appignanese | 0-1 |
| 2021-11-14 | Montemilone P. - San Biagio | 3-0 |
| 2021-11-14 | Settempeda - San Claudio | 3-1 |
| 2021-11-14 | Urbis Salvia - Camerino | 0-0 |
| 9ª Giornata | ||
| 2021-11-21 | Camerino - Caldarola GNC | 1-2 |
| 2021-11-21 | Castelraimondo - Settempeda | 1-0 |
| 2021-11-21 | Matelica - Casette Verd. | 0-0 |
| 2021-11-21 | Montemilone P. - E. Cascinare | 1-1 |
| 2021-11-21 | Pioraco - Elfa Tolentino | 1-2 |
| 2021-11-21 | San Biagio - CSKA Amatori | 3-1 |
| 2021-11-21 | San Claudio - Urbis Salvia | 1-1 |
| 2021-11-21 | Villa Musone - Appignanese | 0-4 |
| 10ª Giornata | ||
| 2021-11-28 | Appignanese - Castelraimondo | 1-0 |
| 2021-11-28 | Caldarola GNC - Pioraco | 3-0 |
| 2021-11-28 | Casette Verd. - Camerino | 3-0 |
| 2021-11-28 | CSKA Amatori - Matelica | 2-4 |
| 2021-11-28 | E. Cascinare - San Claudio | 1-1 |
| 2021-11-28 | Elfa Tolentino - Villa Musone | 3-1 |
| 2021-11-28 | Settempeda - Montemilone P. | 0-0 |
| 2021-11-28 | Urbis Salvia - San Biagio | 1-0 |
| 11ª Giornata | ||
| 2021-12-05 | Camerino - Appignanese | 1-0 |
| 2021-12-05 | E. Cascinare - Urbis Salvia | 2-0 |
| 2021-12-05 | Matelica - Elfa Tolentino | 1-0 |
| 2021-12-05 | Montemilone P. - CSKA Amatori | 0-0 |
| 2021-12-05 | Pioraco - Castelraimondo | 0-1 |
| 2021-12-05 | San Biagio - Caldarola GNC | 1-2 |
| 2021-12-05 | San Claudio - Casette Verd. | 0-1 |
| 2021-12-05 | Villa Musone - Settempeda | 1-2 |
| 12ª Giornata | ||
| 2021-12-12 | Appignanese - Pioraco | 2-2 |
| 2021-12-12 | Caldarola GNC - Matelica | 2-1 |
| 2021-12-12 | Casette Verd. - San Biagio | 3-1 |
| 2021-12-12 | Castelraimondo - Villa Musone | 4-1 |
| 2021-12-12 | CSKA Amatori - San Claudio | 1-3 |
| 2021-12-12 | Elfa Tolentino - Camerino | 1-2 |
| 2021-12-12 | Settempeda - E. Cascinare | 0-0 |
| 2021-12-12 | Urbis Salvia - Montemilone P. | 0-1 |
| 13ª Giornata | ||
| 2021-12-19 | Camerino - Castelraimondo | 1-1 |
| 2021-12-19 | E. Cascinare - CSKA Amatori | 0-1 |
| 2021-12-19 | Matelica - Appignanese | 3-1 |
| 2021-12-19 | Montemilone P. - Casette Verd. | 2-2 |
| 2021-12-19 | Pioraco - Villa Musone | 2-0 |
| 2021-12-19 | San Biagio - Elfa Tolentino | 0-4 |
| 2021-12-19 | San Claudio - Caldarola GNC | 0-1 |
| 2021-12-19 | Urbis Salvia - Settempeda | 0-3 |
| 14ª Giornata | ||
| 2021-01-09 | Appignanese - San Claudio | 0-2 |
| 2021-01-09 | Caldarola GNC - E. Cascinare | 0-2 |
| 2021-01-09 | Casette Verd. - Urbis Salvia | 0-0 |
| 2021-01-09 | Castelraimondo - San Biagio | 2-2 |
| 2021-01-09 | CSKA Amatori - Settempeda | 0-1 |
| 2021-01-09 | Elfa Tolentino - Montemilone P. | 1-1 |
| 2021-01-09 | Pioraco - Camerino | 2-1 |
| 2021-01-09 | Villa Musone - Matelica | 2-4 |
| 15ª Giornata | ||
| 2021-01-16 | Camerino - Villa Musone | 1-2 |
| 2021-01-16 | E. Cascinare - Casette Verd. | 2-1 |
| 2021-01-16 | Matelica - Castelraimondo | 4-0 |
| 2021-01-16 | Montemilone P. - Caldarola GNC | 2-2 |
| 2021-01-16 | San Biagio - Appignanese | 0-3 |
| 2021-01-16 | San Claudio - Elfa Tolentino | 1-2 |
| 2021-01-16 | Settempeda - Pioraco | 3-2 |
| 2021-01-16 | Urbis Salvia - CSKA Amatori | 2-1 |
| RITORNO | ||
| 16ª Giornata | ||
| 2021-01-23 | CSKA Amatori - Caldarola GNC | 1-1 |
| 2021-01-23 | E. Cascinare - Appignanese | 0-2 |
| 2021-01-23 | Matelica - Camerino | 2-0 |
| 2021-01-23 | Montemilone P. - Castelraimondo | 2-1 |
| 2021-01-23 | San Biagio - Pioraco | 1-0 |
| 2021-01-23 | San Claudio - Villa Musone | 1-3 |
| 2021-01-23 | Settempeda - Casette Verd. | 0-2 |
| 2021-01-23 | Urbis Salvia - Elfa Tolentino | 1-0 |
| 17ª Giornata | ||
| 2021-01-30 | Appignanese - Montemilone P. | 1-0 |
| 2021-01-30 | Caldarola GNC - Urbis Salvia | 3-2 |
| 2021-01-30 | Camerino - Settempeda | 3-1 |
| 2021-01-30 | Casette Verd. - CSKA Amatori | 2-0 |
| 2021-01-30 | Castelraimondo - San Claudio | 3-1 |
| 2021-01-30 | Elfa Tolentino - E. Cascinare | 2-2 |
| 2021-01-30 | Pioraco - Matelica | 1- 3 |
| 2021-01-30 | Villa Musone - San Biagio | 2-1 |
| 18ª Giornata | ||
| 2021-02-06 | CSKA Amatori - Appignanese | 3-1 |
| 2021-02-06 | Casette Verd. - Elfa Tolentino | 1-1 |
| 2021-02-06 | E. Cascinare - Villa Musone | 1-0 |
| 2021-02-06 | San Biagio - Matelica | 0-0 |
| 2021-02-06 | Montemilone P. - Pioraco | 1-1 |
| 2021-02-06 | San Claudio - Camerino | 1-2 |
| 2021-02-06 | Settempeda - Caldarola GNC | 0-0 |
| 2021-02-06 | Urbis Salvia - Castelraimondo | 0-1 |
| 19ª Giornata | ||
| 2021-02-13 | Appignanese - Urbis Salvia | 1-0 |
| 2021-02-13 | Caldarola GNC - Casette Verd. | 1-2 |
| 2021-02-13 | Camerino - San Biagio | 3-3 |
| 2021-02-13 | Castelraimondo - E. Cascinare | 3-1 |
| 2021-02-13 | Elfa Tolentino - CSKA Amatori | 2-1 |
| 2021-02-13 | Matelica - Settempeda | 2-0 |
| 2021-02-13 | Pioraco - San Claudio | 1-0 |
| 2021-02-13 | Villa Musone - Montemilone P. | 2-3 |
| 20ª Giornata | ||
| 2021-02-20 | Caldarola GNC - Appignanese | 1-1 |
| 2021-02-20 | Casette Verd. - Castelraimondo | 2-0 |
| 2021-02-20 | CSKA Amatori - Villa Musone | 0-0 |
| 2021-02-20 | E. Cascinare - Camerino | 2-0 |
| 2021-02-20 | Montemilone P. - Matelica | 1-1 |
| 2021-02-20 | San Claudio - San Biagio | 1-0 |
| 2021-02-20 | Settempeda - Elfa Tolentino | 3-2 |
| 2021-02-20 | Urbis Salvia - Pioraco | 3-2 |
| 21ª Giornata | ||
| 2021-02-27 | Appignanese - Casette Verd. | 2-2 |
| 2021-02-27 | Camerino - Montemilone P. | 0-1 |
| 2021-02-27 | Castelraimondo - CSKA Amatori | 2-1 |
| 2021-02-27 | Elfa Tolentino - Caldarola GNC | 0-1 |
| 2021-02-27 | Matelica - San Claudio | 5-0 |
| 2021-02-27 | Pioraco - E. Cascinare | 1-3 |
| 2021-02-27 | San Biagio - Settempeda | 1-1 |
| 2021-02-27 | Villa Musone - Urbis Salvia | 2-0 |
| 22ª Giornata | ||
| 2021-03-06 | Caldarola GNC - Villa Musone | 1-2 |
| 2021-03-06 | Casette Verd. - Pioraco | 3-1 |
| 2021-03-06 | CSKA Amatori - Camerino | 0-1 |
| 2021-03-06 | E. Cascinare - San Biagio | 0-2 |
| 2021-03-06 | Elfa Tolentino - Castelraimondo | 2-0 |
| 2021-03-06 | Montemilone P. - San Claudio | 3-3 |
| 2021-03-06 | Settempeda - Appignanese | 1-0 |
| 2021-03-06 | Urbis Salvia - Matelica | 0-0 |
| 23ª Giornata | ||
| 2021-03-13 | Appignanese - Elfa Tolentino | 0-2 |
| 2021-03-13 | Camerino - Urbis Salvia | 0-0 |
| 2021-03-13 | Castelraimondo - Caldarola GNC | 3-1 |
| 2021-03-13 | Matelica - E. Cascinare | 2-1 |
| 2021-03-13 | Pioraco - CSKA Amatori | 0-0 |
| 2021-03-13 | San Biagio - Montemilone P. | 1-4 |
| 2021-03-13 | San Claudio - Settempeda | 2-0 |
| 2021-03-13 | Villa Musone - Casette Verd. | 0-3 |
| 24ª Giornata | ||
| 2021-03-20 | Appignanese - Villa Musone | 1-0 |
| 2021-03-20 | Caldarola GNC - Camerino | 1-0 |
| 2021-03-20 | Casette Verd. - Matelica | 3-3 |
| 2021-03-20 | CSKA Amatori - San Biagio | 2-1 |
| 2021-03-20 | E. Cascinare - Montemilone P. | 0-2 |
| 2021-03-20 | Elfa Tolentino - Pioraco | 5-1 |
| 2021-03-20 | Settempeda - Castelraimondo | 1-0 |
| 2021-03-20 | Urbis Salvia - San Claudio | 0-0 |
| 25ª Giornata | ||
| 2021-03-27 | Camerino - Casette Verd. | 0-0 |
| 2021-03-27 | Castelraimondo - Appignanese | 1-1 |
| 2021-03-27 | Matelica - CSKA Amatori | 1-0 |
| 2021-03-27 | Montemilone P. - Settempeda | 3-3 |
| 2021-03-27 | Pioraco - Caldarola GNC | 1-0 |
| 2021-03-27 | San Biagio - Urbis Salvia | 1-1 |
| 2021-03-27 | San Claudio - E. Cascinare | 1-1 |
| 2021-03-27 | Villa Musone - Elfa Tolentino | 1-1 |
| 26ª Giornata | ||
| 2021-04-03 | Appignanese - Camerino | 0-0 |
| 2021-04-03 | Caldarola GNC - San Biagio | 4-1 |
| 2021-04-03 | Casette Verd. - San Claudio | 2-1 |
| 2021-04-03 | Castelraimondo - Pioraco | 1-0 |
| 2021-04-03 | CSKA Amatori - Montemilone P. | 0-2 |
| 2021-04-03 | Elfa Tolentino - Matelica | 2-2 |
| 2021-04-03 | Settempeda - Villa Musone | 5-2 |
| 2021-04-03 | Urbis Salvia - E. Cascinare | 3-0 |
| 27ª Giornata | ||
| 2021-04-10 | Camerino - Elfa Tolentino | 0-0 |
| 2021-04-10 | E. Cascinare - Settempeda | 0-1 |
| 2021-04-10 | Matelica - Caldarola GNC | 4-1 |
| 2021-04-10 | Montemilone P. - Urbis Salvia | 1-0 |
| 2021-04-10 | Pioraco - Appignanese | 1-3 |
| 2021-04-10 | San Biagio - Casette Verd. | 0-1 |
| 2021-04-10 | San Claudio - CSKA Amatori | 3-2 |
| 2021-04-10 | Villa Musone - Castelraimondo | 0-2 |
| 28ª Giornata | ||
| 2021-04-16 | Appignanese - Matelica | - |
| 2021-04-16 | Caldarola GNC - San Claudio | - |
| 2021-04-16 | Casette Verd. - Montemilone P. | - |
| 2021-04-16 | Castelraimondo - Camerino | - |
| 2021-04-16 | CSKA Amatori - E. Cascinare | - |
| 2021-04-16 | Elfa Tolentino - San Biagio | - |
| 2021-04-16 | Settempeda - Urbis Salvia | - |
| 2021-04-16 | Villa Musone - Pioraco | - |
| 29ª Giornata | ||
| 2021-04-24 | Camerino - Pioraco | - |
| 2021-04-24 | E. Cascinare - Caldarola GNC | - |
| 2021-04-24 | Matelica - Villa Musone | - |
| 2021-04-24 | Montemilone P. - Elfa Tolentino | - |
| 2021-04-24 | San Biagio - Castelraimondo | - |
| 2021-04-24 | San Claudio - Appignanese | - |
| 2021-04-24 | Settempeda - CSKA Amatori | - |
| 2021-04-24 | Urbis Salvia - Casette Verd. | - |
| 30ª Giornata | ||
| 2021-05-01 | Appignanese - San Biagio | - |
| 2021-05-01 | Caldarola GNC - Montemilone P. | - |
| 2021-05-01 | Casette Verd. - E. Cascinare | - |
| 2021-05-01 | Castelraimondo - Matelica | - |
| 2021-05-01 | CSKA Amatori - Urbis Salvia | - |
| 2021-05-01 | Elfa Tolentino - San Claudio | - |
| 2021-05-01 | Pioraco - Settempeda | - |
| 2021-05-01 | Villa Musone - Camerino | - |